反应详情

温度

90 °C

To a stirred solution of methane sulfonate (930 mg, 3.70 mmol, Example 316) in dimethylformamide (20 mL), sodium azide (962 mg, 14.8 mmol, Aldrich) was added and the mixture was stirred at 90° C. overnight. The mixture was poured into water and extracted with ethyl acetate (5×10 mL) and the extracts were combined, washed with water, brine and dried with sodium sulfate. The solvent was removed to give a clear oil. 710 mg, 97%. The compound was directly used for the next step.

1. extractionextracted with ethyl acetate (5×10 mL)
2. washwashed with water, brine
3. dry with materialdried with sodium sulfate
4. customThe solvent was removed
5. customto give a clear oil