HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1371855Generated: October 26, 2026
Nitromethane → 2-Nitrovinyl-5-cyano-1H-indole
https://huagongshe.com/reaction/1371855
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 3-Formyl-1H-indole-5-carbonitrile | HCID 28504 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Product | 2-Nitrovinyl-5-cyano-1H-indole | HCID 69850620 | — |
Reaction Steps
Combine 3-formyl-5-cyano-1H-indole (10.60 g, 63.32 mmol) and a solution of ammonium acetate (10.60 g) in nitromethane (660 ml). Heat to 90° C. After 2 hours, cool to ambient temperature to give a precipitate. Collect the precipitate by filtration, wash with 1:1 MeOH/water (500 ml), and dry to give the title compound: mp 247–251° C. MS (ACPI): m/e 214.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07157488B2 |
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| Source dataset | uspto-grants-2007_01 |
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| ORD ID | ord-6ff82343e32349d3b0127c8cde43532f |
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| Source note | uspto-grants-2007_01 |
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