反应详情

Combine 3-propoxybenzaldehyde (29.6 mg; 0.18 mmol) and 5-fluorotryptamine (14.2 mg; 0.080 mmol) in methanol (2 mL). Add a solution of sodium borohydride in diglyme (1 ml of a 0.5 M solution; 0.50 mmol)and agitate. After 63 h at room temperature concentrate in a stream of nitrogen. Dissolve the residue in methanol and add to a 1 gm SCX column previously rinsed with 5% acetic acid in methanol. Elute the product from the SCX column with 1 M ammonia in methanol to give the title compound: MS (ES+): m/e (M+1); HPLC (10–90% water/acetonitrile over 10 min, Tr=4.08 min.

1. concentrationAfter 63 h at room temperature concentrate in a stream of nitrogen
2. dissolutionDissolve the residue in methanol
3. additionadd to a 1 gm SCX column
4. washpreviously rinsed with 5% acetic acid in methanol
5. washElute the product from the SCX column with 1 M ammonia in methanol