Chlorosuccinimide → 4-chloro-3,5-bis(trifluoromethyl)-1H-pyrazole

HRID 1372018Notes

Reaction equation

HRID 1372018 reaction equation

[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[NH:5][N:4]=1.C1C(=O)N([Cl:21])C(=O)C1>CC#N>[Cl:21][C:7]1[C:6]([C:8]([F:9])([F:10])[F:11])=[N:5][NH:4][C:3]=1[C:2]([F:1])([F:12])[F:13]

Participants

4

Reactant 2

HCID 31398Chlorosuccinimide

HCID 5189913,5-Bis(trifluoromethyl)pyrazole

Product 1

HCID 101986334-chloro-3,5-bis(trifluoromethyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following protocol L, 3,5-bistrifluoromethyl-1H-pyrazole was treated with NCS in CH3CN to yield the title compound.

Sources & evidence

ORD record: ord-437af777c2ea42d9a8686d8bbae02f01
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157464B2

Reaction notes

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