Dimethylformamide → 2-(3,5-Bis-trifluoromethyl-pyrazol-1-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone

Participants

Reaction Steps

Protocol T was followed using 3,5-Bis-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/1) afforded the title compound as a white solid. 1H NMR (400 MHz, CDCl3): 6.94–7.0 (m, 2H), 6.92 (s, 1H), 6.82–7.90 (dd, 2H), 5.2 (s, 2H), 3.72–3.8 (t, 2H), 3.58–3.66 (t, 2H), 3.12–3.18 (t, 2H), 3.02–3.12 (t, 2H). 13C NMR (400 MHz, CDCl3): 162.2, 158.2, 156.4, 146.5, 118.4, 116.2, 115.8, 113.2, 60.4, 53.2, 50.6, 50.2, 45.2, 42.2, 21.2, 14.2.

Provenance & Evidence