1-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazine → 5-(4-Chloro-3-methyl-phenyl)-7-difluoromethyl-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-pyrazolo[1,5-a]pyrimidine

HRID 137212Notes

Reaction equation

HRID 137212 reaction equation
[Br:23][c:24]1[cH:25][cH:26][c:27]([S:29](=[O:30])(=[O:31])[N:32]2[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]2)[s:28]1.[Cl:1][c:2]1[c:3]([CH3:22])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]([F:15])[F:16])[cH:13]2)[n:17][cH:18][c:19]3[C:20]#[CH:21])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([CH3:22])[cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]([F:15])[F:16])[cH:13]2)[n:17][cH:18][c:19]3[C:20]#[C:21][c:24]2[cH:25][cH:26][c:27]([S:29](=[O:30])(=[O:31])[N:32]3[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]3)[s:28]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 6621571-[(5-Bromo-2-thienyl)sulfonyl]-4-methylpiperazineHCID 866080845-(4-Chloro-3-methyl-phenyl)-7-difluoromethyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670010395-(4-Chloro-3-methyl-phenyl)-7-difluoromethyl-3-[5-(4-methyl-piperazine-1-sulfonyl)-thiophen-2-ylethynyl]-pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record
ord-dfe07de3566e4457ae1fee38b0fe6730
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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