反应详情

Part B: The above-obtained amide was dissolved in acetone (80 mL), to which potassium carbonate (15.75 g, 114.1 mmol) and iodomethane (9.6 mL, 114.1 mmol) were added. The reaction was heated to reflux for 2 hours and cooled, and the resulting solid was filtered. The solvent was removed from the filtrate. The residue was dissolved in dichloromethane, washed with water and brine, and dried over sodium sulfate. After filtration and removal of solvent, the solid was further dried in vacuo to give the desired 2,2,2-trifluoro-N-(4-iodo-phenyl)-N-methyl-acetamide as a white solid. MS found: (M+1)+=330.05.

1. additionwere added
2. temperatureThe reaction was heated
3. temperatureto reflux for 2 hours
4. temperaturecooled
5. filtrationthe resulting solid was filtered
6. customThe solvent was removed from the filtrate
7. dissolutionThe residue was dissolved in dichloromethane
8. washwashed with water and brine
9. dry with materialdried over sodium sulfate
10. filtrationAfter filtration and removal of solvent
11. customthe solid was further dried in vacuo