1-Methylpiperazine → 3-methyl-5-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde

HRID 1372404Notes

Reaction equation

HRID 1372404 reaction equation
[CH:1]([C:3]1[NH:7][C:6]([C:8]([OH:10])=O)=[CH:5][C:4]=1[CH3:11])=[O:2].[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:11][C:4]1[CH:5]=[C:6]([C:8]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)=[O:10])[NH:7][C:3]=1[CH:1]=[O:2]

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 98988845-formyl-4-methyl-1H-pyrrole-2-carboxylic Acid

Product 1

HCID 221354543-methyl-5-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde

Procedure

5-Formyl-4-methyl-1H-pyrrole-2-carboxylic acid was amidated with 1-methylpiperazine using General Amidation Procedure 1 to give 3-Methyl-5-(4-methyl-piperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde. MS m/z 236 [M+1].

Sources & evidence

ORD record
ord-611092fd28cb4b76a76210dbf6f87006
Source dataset
uspto-grants-2007_01
Patent number
US07157577B2

Reaction notes

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