1-Methylpiperazine → HCID 21071893, compound

HRID 1372425Notes

Reaction equation

[CH:1]([C:3]1[NH:7][C:6]([CH3:8])=[C:5]([C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([OH:14])=O)[C:4]=1[CH3:18])=[O:2].[CH3:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:18][C:4]1[C:5]([C:9]2[CH:17]=[CH:16][CH:15]=[C:11]([C:12]([N:23]3[CH2:24][CH2:25][N:20]([CH3:19])[CH2:21][CH2:22]3)=[O:14])[CH:10]=2)=[C:6]([CH3:8])[NH:7][C:3]=1[CH:1]=[O:2]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 21071898HCID 21071898, compound

Product 1

HCID 21071893HCID 21071893, compound

Procedure

3-(5-Formyl-2,4-dimethyl-1H-pyrrol-3-yl)-benzoic acid was reacted with 1-methylpiperazine using General Amidation Procedure 1 to give 3,5-dimethyl-4-[3-(4-methyl-piperazine-1-carbonyl)-phenyl]-1H-pyrrole-2-carbaldehyde. MS m/z 326 [M+1].

Sources & evidence

ORD record: ord-15e3f75155654e169fddee51f50f3a6e
Source dataset: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07157577B2

Reaction notes

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