Dichloromethane → HCID 21071766, compound

A 1-L, round bottom flask was charged with 12.64 g (51.4 mmol) of benzyl 4-oxo-1-piperidinecarboxylate and 300 mL of dichloromethane. To the stirring solution at −78° C. was added 19 mL (102.8 mmol) of [bis(2-methoxyethyl)amino]sulfur trifluoride via addition funnel over a period of about 1 h. The reaction mixture was allowed to warm slowly to ambient temperature overnight. The reaction mixture was added portionwise with caution to a large extractor containing water and saturated aqueous sodium bicarbonate solution. The mixture was extracted with dichloromethane (3×300 mL). The combined organic layers were washed once with saturated aqueous sodium bicarbonate solution, twice with 10% aqueous hydrochloric acid solution and saturated aqueous brine, dried over sodium sulfate, and concentrated in vacuo. Purification by flash chromatography on a Biotage® system (gradient, hexane to 65% ethyl acetate/hexane) afforded the desired product. LC/MS 242.1 (M+1).

1. additionvia addition funnel over a period of about 1 h
2. additionThe reaction mixture was added portionwise with caution to a large extractor
3. extractionThe mixture was extracted with dichloromethane (3×300 mL)
4. washThe combined organic layers were washed once with saturated aqueous sodium bicarbonate solution, twice with 10% aqueous hydrochloric acid solution and saturated aqueous brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customPurification by flash chromatography on a Biotage® system (gradient, hexane to 65% ethyl acetate/hexane)

ORD record

ord-21f71abe3fe84a518587ce5adfbe0da8

Source dataset

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07157490B2