反应详情

温度

90 °C

The crude diketone from step 7 (approx. 10.6 mmol) was dissolved in toluene (106 mL) and treated with acetic acid (0.606 mL, 10.6 mmol) and pyrrolidine (0.883 mL, 10.6 mmol). The resulting solution was stirred and heated in an oil bath at 90° C. for 3.5 hours. After cooling to room temperature, the mixture was filtered through a pad of silica gel and the product washed off with EtOAc. The filtrate and washings were concentrated under vacuum. The residue was purified by flash chromatography on a Biotage 40M KP-Sil column, eluting with 4:1 hexanes-EtOAc. The product containing fractions were evaporated under vacuum to provide 7-amino-9a-butyl-8-chloro-6-fluoro-1,2,9,9a-tetrahydro-3H-fluoren-3-one (2.7 g, 83%) as a yellow solid.

1. temperatureAfter cooling to room temperature
2. filtrationthe mixture was filtered through a pad of silica gel
3. washthe product washed off with EtOAc
4. concentrationThe filtrate and washings were concentrated under vacuum
5. customThe residue was purified by flash chromatography on a Biotage 40M KP-Sil column
6. washeluting with 4:1 hexanes-EtOAc
7. additionThe product containing fractions
8. customwere evaporated under vacuum