Methanol → 2-Phenylaminobenzoxazol-6-acetic acid

Participants

Reaction Steps

In tetrahydrofuran (which will hereinafter be abbreviated as “THF”) (2 ml) and methanol (2 ml) was dissolved methyl 2-phenylaminobenzoxazol-6-acetate (460 mg, 1.63 mmol), followed by the addition of 1N NaOH (3.3 ml) under stirring at room temperature. After further stirring overnight at room temperature, the reaction mixture was concentrated into a small volume. The concentrate was acidified with acetic acid. The crystals thus obtained were collected by filtration, washed with water and then dried, whereby 2-phenylaminobenzoxazol-6-acetic acid (348 mg, 80%) was obtained as a pale yellow solid.

Provenance & Evidence