反应详情

In tetrahydrofuran (which will hereinafter be abbreviated as “THF”) (2 ml) and methanol (2 ml) was dissolved methyl 2-phenylaminobenzoxazol-6-acetate (460 mg, 1.63 mmol), followed by the addition of 1N NaOH (3.3 ml) under stirring at room temperature. After further stirring overnight at room temperature, the reaction mixture was concentrated into a small volume. The concentrate was acidified with acetic acid. The crystals thus obtained were collected by filtration, washed with water and then dried, whereby 2-phenylaminobenzoxazol-6-acetic acid (348 mg, 80%) was obtained as a pale yellow solid.

1. stirringAfter further stirring overnight at room temperature
2. concentrationthe reaction mixture was concentrated into a small volume
3. customThe crystals thus obtained
4. filtrationwere collected by filtration
5. washwashed with water
6. customdried