反应详情

A mixture of diethyl 3-benzyloxy-4-nitrophenylmalonate (22.0 g, 57.8 mmol), acetic acid (200 ml) and concentrated hydrochloric acid (100 ml) was heated under reflux for 15 hours under stirring. After the reaction mixture was cooled to room temperature, the solvent was distilled off from the reaction mixture under reduced pressure. The solid thus obtained was collected by filtration under reduced pressure, followed by drying under reduced pressure, whereby the title compound (5.45 g, 48%) was obtained as a pale yellow amorphous substance.

1. temperaturewas heated
2. temperatureunder reflux for 15 hours
3. distillationthe solvent was distilled off from the reaction mixture under reduced pressure
4. customThe solid thus obtained
5. filtrationwas collected by filtration under reduced pressure
6. dry with materialby drying under reduced pressure, whereby the title compound (5.45 g, 48%)
7. customwas obtained as a pale yellow amorphous substance