反应详情

In THF (200 ml) was dissolved methyl 2-(2-chlorophenylamino)-6-benzoxazolylacetate (3.35 g, 10.6 mmol). After addition of 0.25N NaOH (200 ml), the mixture was stirred at room temperature for 16 hours. The reaction mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl, followed by extraction with a chloroform/methanol (10/1) mixture. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent, whereby the title compound (2.94 g, 92%) was obtained as a pale brown solid.

1. distillationThe reaction mixture was distilled under reduced pressure
2. customto remove the solvent
3. extractionfollowed by extraction with a chloroform/methanol (10/1) mixture
4. washThe extract was washed with saturated brine
5. dry with materialdried over anhydrous sodium sulfate
6. distillationdistilled under reduced pressure
7. customto remove the solvent, whereby the title compound (2.94 g, 92%)
8. customwas obtained as a pale brown solid