Hydrochloric Acid → 2-Fluoro-3-hydroxy-4-nitrophenylacetic acid

Participants

Reaction Steps

Di-tert-butyl (3-benzyloxy-2-fluoro-4-nitrophenyl)malonate (6.87 g, 14.9 mmol), acetic acid (200 ml) and concentrated hydrochloric acid (35 ml) were stirred at 120° C. for 6 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure, whereby the title compound was obtained as a brown oil (this compound was provided for the subsequent reaction without further purification).

Provenance & Evidence