Hydrochloric Acid → 2-Fluoro-3-hydroxy-4-nitrophenylacetic acid

HRID 1372572Notes

Reaction equation

HRID 1372572 reaction equation
C([O:8][C:9]1[C:10]([F:33])=[C:11]([CH:18](C(OC(C)(C)C)=O)[C:19]([O:21]C(C)(C)C)=[O:20])[CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])C1C=CC=CC=1.Cl>C(O)(=O)C>[F:33][C:10]1[C:9]([OH:8])=[C:14]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:12][C:11]=1[CH2:18][C:19]([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67406367HCID 67406367, compound

Product 1

HCID 587784902-Fluoro-3-hydroxy-4-nitrophenylacetic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Di-tert-butyl (3-benzyloxy-2-fluoro-4-nitrophenyl)malonate (6.87 g, 14.9 mmol), acetic acid (200 ml) and concentrated hydrochloric acid (35 ml) were stirred at 120° C. for 6 hours. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure, whereby the title compound was obtained as a brown oil (this compound was provided for the subsequent reaction without further purification).

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure, whereby the title compound
  2. customwas obtained as a brown oil (this compound
  3. customwas provided for the subsequent reaction without further purification)

Sources & evidence

ORD record
ord-440e16a1e17a46c7ac22f6000529ba7c
Source dataset
uspto-grants-2007_01
Patent number
US07157487B2

Reaction notes

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