反应详情

To a solution of methyl 4-((2S,4S)-1-(2-(2-methylphenylamino)-6-benzoxazolylacetyl)-4-(2-naphthyloxy)-2-pyrrolidinylmethoxy)benzoate (312 mg, 0.486 mmol) in THF (20 ml) was added 0.25N NaOH (20 ml). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was then concentrated under reduced pressure. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure, whereby the title compound (253 mg, 83%) was obtained as a pale pink solid.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. customThe crystals thus precipitated
3. filtrationwere collected by filtration under reduced pressure
4. washwashed with water
5. dry with materialdried under reduced pressure, whereby the title compound (253 mg, 83%)
6. customwas obtained as a pale pink solid