Trifluoroacetic acid → HCID 58778388, compound

Methyl 5-((2S,4S)-1-(tert-butoxycarbonyl)-4-fluoro-2-pyrrolidinylmethoxy)pentanoate (1.09 g, 3.27 mmol) was dissolved in methylene chloride (50 ml). At room temperature, trifluoroacetic acid (10 ml) was added to the resulting solution. The mixture was stirred at the same temperature for 3.5 hours. The residue obtained by distilling off the solvent under reduced pressure was diluted with methylene chloride (50 ml). The solution was basified with 1N NaOH, followed by extraction with methylene chloride. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and distilled under reduced pressure to remove the solvent, whereby the title compound (590 mg, 77%) was obtained as a yellow oil (this compound was provided for the subsequent reaction without further purification).

1. customThe residue obtained
2. distillationby distilling off the solvent under reduced pressure
3. additionwas diluted with methylene chloride (50 ml)
4. extractionfollowed by extraction with methylene chloride
5. washThe extract was washed with saturated brine
6. dry with materialdried over anhydrous sodium sulfate
7. distillationdistilled under reduced pressure
8. customto remove the solvent, whereby the title compound (590 mg, 77%)
9. customwas obtained as a yellow oil (this compound
10. customwas provided for the subsequent reaction without further purification)

ORD record

ord-0808868cad7f4657904182285e2dd380

Source dataset

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07157487B2