反应详情

To a solution of (Z)-4-benzyloxy-2-buten-1-ol (2.0 g, 11.2 mmol) in methylene chloride (40 ml) were added carbon tetrabromide (4.46 g, 13.4 mmol) and triphenylphosphine (3.51 g, 13.4 mmol) at 0° C. under stirring in a nitrogen gas stream. After stirring at room temperature for 1.5 hours, the reaction mixture was concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column (silica gel: 50 g), whereby from hexane/ethyl acetate (4/1) eluate fractions, the title compound (2.76 g, 100%) was obtained as a colorless oil.

1. stirringAfter stirring at room temperature for 1.5 hours
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. customThe residue was purified by chromatography on a silica gel column (silica gel: 50 g), whereby from hexane/ethyl acetate (4/1) eluate fractions