反应详情

To a solution of methyl (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetate (1.73 g, 5.50 mmol) in THF/methanol (2:1, 30 ml) was added 1N NaOH (20 ml). After stirring at room temperature for 3.5 hours, the mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetic acid (1.60 g, 97%) as a colorless crystalline powder.

1. distillationthe mixture was distilled under reduced pressure
2. customto remove the solvent
3. customThe crystals thus precipitated
4. filtrationwere collected by filtration under reduced pressure
5. washwashed with water
6. customdried under reduced pressure