Sodium Hydroxide → (2-(5-Fluoro-2-methylphenylamino)-6-benzoxazolyl)acetic acid

Participants

Reaction Steps

To a solution of methyl (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetate (1.73 g, 5.50 mmol) in THF/methanol (2:1, 30 ml) was added 1N NaOH (20 ml). After stirring at room temperature for 3.5 hours, the mixture was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (2-(5-fluoro-2-methylphenylamino)-6-benzoxazolyl)acetic acid (1.60 g, 97%) as a colorless crystalline powder.

Provenance & Evidence