4-Fluoro-2-nitrophenol → 2-Amino-4-fluorophenol

Participants

Reaction Steps

In methanol (20 ml) was dissolved 4-fluoro-2-nitrophenol (1.00 g, 6.37 mmol). To the resulting solution was added 10% palladium-carbon (0.20 g, 20 wt %). The resulting mixture was subjected to catalytic hydrogenation under stirring for 2 days. After the reaction mixture was filtered through Celite to remove the catalyst, the filtrate was distilled under reduced pressure to remove the solvent, whereby 2-amino-4-fluorophenol (850 mg, 100%) was obtained as a reddish brown solid.

Provenance & Evidence