2-Chlorobenzoxazole → HCID 58778646, compound

Participants

Reaction Steps

A mixture of 2-chlorobenzoxazole (489 mg, 2.88 mmol) and methyl 4-amino-3-chlorophenylacetate (567 mg, 2.84 mmol) and pyridinium•p-toluenesulfonate (pyridinium•p-toluenesulfonate (PPTS)) (214 mg, 0.85 mmol) was heated under reflux for 3 hours in xylene (10 ml). After the reaction mixture was cooled to room temperature, the solvent was distilled off under reduced pressure. The residue was purified by chromatography on a silica gel column, whereby from n-hexane/ethyl acetate (7:1, v/v) eluate fractions, methyl (4-(2-benzothiazolyl)amino-3-chlorophenyl)acetate (296 mg, 32%) was obtained as a white solid.

Provenance & Evidence