反应详情

Methyl (3-chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetate (158 mg, 0.45 mmol) was dissolved in THF (3 ml). To the resulting solution was added 0.5N NaOH (3.0 ml, 1.50 mmol), and the resulting mixture was stirred at room temperature for 18 hours. The mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (3-chloro-4-(6-fluoro-2-benzothiazolyl)aminophenyl)acetic acid (127 mg, 84%) as a pale yellow solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure