反应详情

In THF (5 ml) was dissolved methyl (4-(4-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate (556 mg, 1.51 mmol). To the resulting solution was added 1N NaOH (4.5 ml, 4.50 mmol), followed by stirring at room temperature for 20 hours. The mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(4-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid (468 mg, 88%) as a pale yellow solid.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure