反应详情

温度

50 °C

In THF (6.0 ml) was dissolved methyl 3-chloro-4-((1-ethyl-3-indolylcarbonyl)amino)phenylacetate. To the resulting solution was added 0.25N NaOH (6.0 ml) at room temperature. After stirring at 50° C. for 18 hours, the reaction mixture was cooled to room temperature and distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl (2.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and then, dried under reduced pressure to give 3-chloro-4-((1-ethyl-3-indolylcarbonyl)amino)phenylacetic acid (250.7 mg, 94%) as a brown amorphous substance.

1. temperaturethe reaction mixture was cooled to room temperature
2. distillationdistilled under reduced pressure
3. customto remove the solvent
4. customThe crystals thus precipitated
5. filtrationwere collected by filtration under reduced pressure
6. washwashed with water
7. customdried under reduced pressure