反应详情

In acetone (95 ml) was dissolved 4-fluoro-1-methylindole-3-carbaldehyde (1.43 g, 8.08 mmol), followed by the addition of potassium permanganate (a 0.2M aqueous solution, 62.0 ml, 12.4 mmol) in portions at room temperature. After the reaction mixture was stirred at room temperature for 16 hours, the precipitate was filtered off through Celite. The filtrate was distilled under reduced pressure to remove the solvent. The residue was acidified with 1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give 4-fluoro-1-methylindole-3-carboxylic acid (0.91 g, 58%) as a brown solid.

1. filtrationthe precipitate was filtered off through Celite
2. distillationThe filtrate was distilled under reduced pressure
3. customto remove the solvent
4. customThe crystals thus precipitated
5. filtrationwere collected by filtration under reduced pressure
6. washwashed with water
7. customdried under reduced pressure