Sodium Hydroxide → HCID 17859101, compound

HRID 1372769Notes

Reaction equation

HRID 1372769 reaction equation
[F:1][C:2]1[C:10]2[O:9][C:8]([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH:14]=[CH:13][N:12]=3)=[N:7][C:6]=2[CH:5]=[CH:4][C:3]=1[CH2:21][C:22]([O:24]C)=[O:23].[OH-].[Na+]>C1COCC1>[F:1][C:2]1[C:10]2[O:9][C:8]([C:11]3[C:20]4[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=4)[CH:14]=[CH:13][N:12]=3)=[N:7][C:6]=2[CH:5]=[CH:4][C:3]=1[CH2:21][C:22]([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 58778962HCID 58778962, compound

Product 1

HCID 17859101HCID 17859101, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To methyl (7-fluoro-2-(1-isoquinolinyl)-6-benzoxazolyl)acetate (155 mg, 0.46 mmol) were added THF (3 ml) and 0.5N NaOH (3.0 ml, 1.50 mmol). The resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was poured in ice-1N HCl to acidify the mixture therewith. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (7-fluoro-2-(1-isoquinolinyl)-6-benzoxazolyl)acetic acid (116 mg, 78%) as a brown solid.

Workup

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-e3c77b00b68c4495a9c0a2600f135888
Source dataset
uspto-grants-2007_01
Patent number
US07157487B2

Reaction notes

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