反应详情

Ethyl (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetate (531 mg, 1.41 mmol) was dissolved in methanol (50 ml). To the resulting solution was added 0.25N NaOH (12 ml, 3 mmol). The resulting mixture was stirred at room temperature for 15 hours. The reaction mixture was poured in 1N HCl (100 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure for 15 hours to give (5-chloro-2-fluoro-4-(3-indazolylcarbonylamino)phenyl)acetic acid (480 mg, 98%) as a colorless crystalline powder.

1. customThe crystals thus precipitated
2. filtrationwere collected by filtration under reduced pressure
3. washwashed with water
4. customdried under reduced pressure for 15 hours