Lithium hydroxide, monohydrate → HCID 21072057, compound

HRID 1372805Notes

Reaction equation

HRID 1372805 reaction equation
[OH:1][C@H:2]1[C@H:9]2[C@:5]([C:12]([O:14]C)=[O:13])([O:6][C:7]([CH3:11])([CH3:10])[O:8]2)[O:4][C@H:3]1[CH2:16][NH:17][C:18](=[O:60])[CH2:19][NH:20][C:21](=[O:59])[CH2:22][N:23]1[CH2:34][CH2:33][N:32]([CH2:35][C:36](=[O:42])[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])[CH2:31][CH2:30][N:29]([CH2:43][C:44](=[O:50])[O:45][C:46]([CH3:49])([CH3:48])[CH3:47])[CH2:28][CH2:27][N:26]([CH2:51][C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:25][CH2:24]1.O[Li].O>CO>[OH:1][C@H:2]1[C@H:9]2[C@:5]([C:12]([OH:14])=[O:13])([O:6][C:7]([CH3:11])([CH3:10])[O:8]2)[O:4][C@H:3]1[CH2:16][NH:17][C:18](=[O:60])[CH2:19][NH:20][C:21](=[O:59])[CH2:22][N:23]1[CH2:34][CH2:33][N:32]([CH2:35][C:36](=[O:42])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:31][CH2:30][N:29]([CH2:43][C:44](=[O:50])[O:45][C:46]([CH3:47])([CH3:48])[CH3:49])[CH2:28][CH2:27][N:26]([CH2:51][C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86591979HCID 86591979, compound

Product 1

HCID 21072057HCID 21072057, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 19a (1.0 g, 1.17 mmol) in MeOH (2 mL) was added a solution of LiOH.H2O (48.5 mg, 1.17 mmol, Aldrich). The resulting solution was stirred at room temperature for 4 h. Solvents were evaporated and the residue was purified by silica column chromatography. Product 20a was obtained as a white solid (0.8 g; yield 81%).

Workup

  1. customSolvents were evaporated
  2. customthe residue was purified by silica column chromatography

Sources & evidence

ORD record
ord-5c3582146e8242e59ae9624f546e6e60
Source dataset
uspto-grants-2007_01
Patent number
US07160535B2

Reaction notes

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