Lithium hydroxide, monohydrate → HCID 86591980, compound

HRID 1372807Notes

Reaction equation

HRID 1372807 reaction equation
[OH:1][C@@H:2]1[C@@H:9]2[C@@:5]([C:12]([O:14]C)=[O:13])([O:6][C:7]([CH3:11])([CH3:10])[O:8]2)[O:4][C@H:3]1[CH2:16][NH:17][C:18]([CH:20]1[CH2:25][CH2:24][CH:23]([CH2:26][NH:27][C:28](=[O:70])[CH2:29][NH:30][C:31](=[O:69])[CH2:32][N:33]2[CH2:44][CH2:43][N:42]([CH2:45][C:46](=[O:52])[O:47][C:48]([CH3:51])([CH3:50])[CH3:49])[CH2:41][CH2:40][N:39]([CH2:53][C:54](=[O:60])[O:55][C:56]([CH3:59])([CH3:58])[CH3:57])[CH2:38][CH2:37][N:36]([CH2:61][C:62]([O:64][C:65]([CH3:68])([CH3:67])[CH3:66])=[O:63])[CH2:35][CH2:34]2)[CH2:22][CH2:21]1)=[O:19].O[Li].O>CO>[OH:1][C@@H:2]1[C@@H:9]2[C@@:5]([C:12]([OH:14])=[O:13])([O:6][C:7]([CH3:11])([CH3:10])[O:8]2)[O:4][C@H:3]1[CH2:16][NH:17][C:18]([CH:20]1[CH2:21][CH2:22][CH:23]([CH2:26][NH:27][C:28](=[O:70])[CH2:29][NH:30][C:31](=[O:69])[CH2:32][N:33]2[CH2:34][CH2:35][N:36]([CH2:61][C:62](=[O:63])[O:64][C:65]([CH3:66])([CH3:67])[CH3:68])[CH2:37][CH2:38][N:39]([CH2:53][C:54](=[O:60])[O:55][C:56]([CH3:57])([CH3:58])[CH3:59])[CH2:40][CH2:41][N:42]([CH2:45][C:46]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:52])[CH2:43][CH2:44]2)[CH2:24][CH2:25]1)=[O:19]

Participants

4

Reactant 2

HCID 168937Lithium hydroxide, monohydrate2×HCID 86591981HCID 86591981, compound

Product 1

HCID 86591980HCID 86591980, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 19b (1.5 g, 1.5 mmol) in MeOH (4 mL) was added a solution of LiOH.H2O (63 mg, 1.5 mmol, Aldrich). The resulting solution was stirred at room temperature for 4 h. 30 mg of LiOH.H2O was added and it was stirred at RT for 20 more hours. Solvents were evaporated to obtain crude product 20b (1.45 g; crude yield 99%). The material was used without further purification.

Workup

  1. stirringit was stirred at RT for 20 more hours
  2. customSolvents were evaporated

Sources & evidence

ORD record
ord-1cfad192889248a0a4d3749b30011329
Source dataset
uspto-grants-2007_01
Patent number
US07160535B2

Reaction notes

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