Trifluoroacetic acid → HCID 21072673, compound

HRID 1372885Notes

Reaction equation

HRID 1372885 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:20]=[N:19][C:18]([C:21]([N:23]3[CH2:28][CH2:27][N:26]([S:29]([C:32]4[CH:41]=[CH:40][C:39]5[C:34](=[CH:35][CH:36]=[C:37]([Cl:42])[CH:38]=5)[CH:33]=4)(=[O:31])=[O:30])[CH2:25][CH2:24]3)=[O:22])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[Cl:42][C:37]1[CH:38]=[C:39]2[C:34](=[CH:35][CH:36]=1)[CH:33]=[C:32]([S:29]([N:26]1[CH2:25][CH2:24][N:23]([C:21]([C:18]3[N:19]=[N:20][C:15]([N:11]4[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]4)=[CH:16][CH:17]=3)=[O:22])[CH2:28][CH2:27]1)(=[O:30])=[O:31])[CH:41]=[CH:40]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21072671HCID 21072671, compound

Product 1

HCID 21072673HCID 21072673, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-[6-(4-t-butoxycarbonylhexahydro-1,4-diazepin-1-yl)pyridazin-3-ylcarbonyl]-4-(6-chloronaphthalen-2-ylsulfonyl)piperazine (0.320 g, 0.52 mmol) in methylene chloride (10 mL) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred overnight at room temperature, and the solvent removed by evaporation. The residue was purified using a SCX column to afford the title product (0.230 g, 86%).

Workup

  1. customthe solvent removed by evaporation
  2. customThe residue was purified

Sources & evidence

ORD record
ord-dea738d1161a40b391069166c3fc2f81
Source dataset
uspto-grants-2007_01
Patent number
US07160878B2

Reaction notes

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