Sodium Hydroxide → HCID 178515246, compound

Participants

Reaction Steps

In the step (c), 1-(4-methoxybenzyl)-1H-[1,2,3]triazolo[4,5-g]phthalazin-4,9-dione prepared in the step (b) is dissolved in TFA and then refluxed for 40–50 hours. NaOH is added in remnants and washed with ethyl acetate, and then 1H-[1,2,3]triazolo[4,5-g]phthalazin-4,9-dione is obtained by acidifying the resulting aqueous layer to pH 1. Examples of halogenated alkylating agents include, but are not limited to, methyl iodide, ethyl iodide, propyl iodide and butyl iodide.

Provenance & Evidence