Sodium Hydroxide → HCID 178515246, compound

HRID 1372896Notes

Reaction equation

HRID 1372896 reaction equation
COC1C=CC(C[N:8]2[C:12]3[C:13](=[O:22])[C:14]4[CH:15]=[N:16][N:17]=[CH:18][C:19]=4[C:20](=[O:21])[C:11]=3[N:10]=[N:9]2)=CC=1.[OH-].[Na+]>C(O)(C(F)(F)F)=O>[NH:8]1[C:12]2[C:13](=[O:22])[C:14]3[CH:15]=[N:16][N:17]=[CH:18][C:19]=3[C:20](=[O:21])[C:11]=2[N:10]=[N:9]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21072872HCID 21072872, compound

Product 1

HCID 178515246HCID 178515246, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In the step (c), 1-(4-methoxybenzyl)-1H-[1,2,3]triazolo[4,5-g]phthalazin-4,9-dione prepared in the step (b) is dissolved in TFA and then refluxed for 40–50 hours. NaOH is added in remnants and washed with ethyl acetate, and then 1H-[1,2,3]triazolo[4,5-g]phthalazin-4,9-dione is obtained by acidifying the resulting aqueous layer to pH 1. Examples of halogenated alkylating agents include, but are not limited to, methyl iodide, ethyl iodide, propyl iodide and butyl iodide.

Workup

  1. temperaturerefluxed for 40–50 hours
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-3032bee955814086b2c14dd935105692
Source dataset
uspto-grants-2007_01
Patent number
US07160884B2

Reaction notes

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