HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → Tert-butyl {3-[2-(1-hydroxy-1-propylbutyl)phenylamino]-1,1-dimethylpropyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate | HCID 11788901 | — |
| Reactant | 4-(2-Aminophenyl)heptan-4-ol | HCID 21072838 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Tert-butyl {3-[2-(1-hydroxy-1-propylbutyl)phenylamino]-1,1-dimethylpropyl}carbamate | HCID 86600980 | — |
Reaction Steps
1.40 g (22.27 mmol) sodium cyanoborohydride are added to a solution of 3.10 g (14.05 mmol) 4-(2-amino-phenyl)-heptan-4-ol and 3.60 g (17.88 mmol) tert-butyl (1,1-dimethyl-3-oxo-propyl)-carbamate in MeOH (40 mL) and AcOH (6 mL). The mixture is stirred for 16 h at RT, diluted with EtOAc and washed with 0.5 M aqueous KHSO4 and saturated. aqueous NaCl , dried with sodium sulphate and evaporated down i. vac. The crude product is used in the next reaction step without any further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160882B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-c9288764caab4f4da0751d4ae27b02d2 |
| Source note | uspto-grants-2007_01 |