反应详情

1.40 g (22.27 mmol) sodium cyanoborohydride are added to a solution of 3.10 g (14.05 mmol) 4-(2-amino-phenyl)-heptan-4-ol and 3.60 g (17.88 mmol) tert-butyl (1,1-dimethyl-3-oxo-propyl)-carbamate in MeOH (40 mL) and AcOH (6 mL). The mixture is stirred for 16 h at RT, diluted with EtOAc and washed with 0.5 M aqueous KHSO4 and saturated. aqueous NaCl , dried with sodium sulphate and evaporated down i. vac. The crude product is used in the next reaction step without any further purification.

1. washwashed with 0.5 M aqueous KHSO4
2. dry with materialaqueous NaCl , dried with sodium sulphate
3. customevaporated down i
4. customThe crude product is used in the next reaction step without any further purification