tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → HCID 86622284, compound

HRID 1372912Notes

Reaction equation

HRID 1372912 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:14])([CH2:12][CH3:13])[CH2:10][CH3:11].[CH3:15][C:16]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:20])[CH2:17][CH:18]=O>>[C:24]([O:23][C:22](=[O:28])[NH:21][C:16]([CH3:20])([CH3:15])[CH2:17][CH2:18][NH:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH2:12][CH3:13])([OH:14])[CH2:10][CH3:11])([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 11788901tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamateHCID 21072832HCID 21072832, compound

Product 1

HCID 86622284HCID 86622284, compound

Procedure

The product is obtained analogously to intermediate product 1b starting from 3-(2-amino-4-fluoro-phenyl)-pentan-3-ol and tert-butyl (1,1-dimethyl-3-oxo-propyl)-carbamate. The crude product is purified by column chromatography (silica gel, dichloromethane/MeOH 100:0→98:2). Yield: 7.70 g (99%).

Workup

  1. customThe crude product is purified by column chromatography (silica gel, dichloromethane/MeOH 100:0→98:2)

Sources & evidence

ORD record
ord-7db84a7244314d079394a87ccd4b3377
Source dataset
uspto-grants-2007_01
Patent number
US07160882B2

Reaction notes

Loading…