tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → HCID 86600981, compound

HRID 1372913Notes

Reaction equation

HRID 1372913 reaction equation
[NH2:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]([OH:15])([CH2:13][CH3:14])[CH2:11][CH3:12].[CH3:16][C:17]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:21])[CH2:18][CH:19]=O>>[CH2:11]([C:10]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([O:8][CH3:9])[C:2]=1[NH:1][CH2:19][CH2:18][C:17]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])([CH3:21])[CH3:16])([OH:15])[CH2:13][CH3:14])[CH3:12]

Participants

3

Reactant 2

HCID 11788901tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamateHCID 21072831HCID 21072831, compound

Product 1

HCID 86600981HCID 86600981, compound

Procedure

The product is obtained analogously to intermediate product 1b starting from 3-(2-amino-3-methoxy-phenyl)-pentan-3-ol and tert-butyl (1,1-dimethyl-3-oxo-propyl)-carbamate. The crude product is purified by column chromatography (silica gel, cyclohexane/EtOAc 4:1). Yield: 4.60 g (47%).

Workup

  1. customThe crude product is purified by column chromatography (silica gel, cyclohexane/EtOAc 4:1)

Sources & evidence

ORD record
ord-69339da2b6c94b8485d797343cb97ec1
Source dataset
uspto-grants-2007_01
Patent number
US07160882B2

Reaction notes

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