2,2,3,3,3-Pentafluoropropylamine → HCID 86596821, compound

HRID 1372946Notes

Reaction equation

HRID 1372946 reaction equation
[F:1][C@@:2]([CH3:25])([C:6]([NH:8][C@@H:9]1[C:15](=[O:16])[NH:14][C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]1=2)=[O:7])[C:3](O)=[O:4].[F:26][C:27]([F:34])([C:30]([F:33])([F:32])[F:31])[CH2:28][NH2:29]>>[F:1][C@:2]([CH3:25])([C:3]([NH:29][CH2:28][C:27]([F:34])([F:26])[C:30]([F:33])([F:32])[F:31])=[O:4])[C:6]([NH:8][C@@H:9]1[C:15](=[O:16])[NH:14][C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]1=2)=[O:7]

Participants

3

Reactant 2

HCID 790022,2,3,3,3-PentafluoropropylamineHCID 69040064HCID 69040064, compound

Product 1

HCID 86596821HCID 86596821, compound

Procedure

In an analogous manner to that described in Example 1 c), the condensation of (2S)-2-fluoro-2-methyl-N-[(S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-malonamic acid and 2,2,3,3,3-pentafluoro-propylamine yielded the title compound as a white solid; MS: m/e=474 (M+H)+; optical integrity 96.4% d.e.

Sources & evidence

ORD record
ord-fc54916d1c9b42e99e223d31dffd1ae4
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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