反应详情

(S)-N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-fluoro-2-methyl-malonamic acid was coupled with 3,3,4,4,4-pentafluoro-butylamine in analogy to the procedure described for example 73 to yield (R)-N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-fluoro-2-methyl-N′-(3,3,4,4,4-pentafluoro-butyl)-malonamide as white solid.