3,3,4,4,4-Pentafluorobutan-1-amine → HCID 86596828, compound

HRID 1372957Notes

Reaction equation

HRID 1372957 reaction equation
[CH:1]1([CH2:4][N:5]2[C:11](=[O:12])[C@@H:10]([NH:13][C:14](=[O:21])[C@@:15]([F:20])([CH3:19])[C:16](O)=[O:17])[C:9]3[CH:22]=[CH:23][CH:24]=[CH:25][C:8]=3[C:7]3[CH:26]=[CH:27][CH:28]=[CH:29][C:6]2=3)[CH2:3][CH2:2]1.[F:30][C:31]([F:39])([C:35]([F:38])([F:37])[F:36])[CH2:32][CH2:33][NH2:34]>>[CH:1]1([CH2:4][N:5]2[C:11](=[O:12])[C@@H:10]([NH:13][C:14](=[O:21])[C@@:15]([F:20])([CH3:19])[C:16]([NH:34][CH2:33][CH2:32][C:31]([F:39])([F:30])[C:35]([F:38])([F:37])[F:36])=[O:17])[C:9]3[CH:22]=[CH:23][CH:24]=[CH:25][C:8]=3[C:7]3[CH:26]=[CH:27][CH:28]=[CH:29][C:6]2=3)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 157547403,3,4,4,4-Pentafluorobutan-1-amineHCID 69043616HCID 69043616, compound

Product 1

HCID 86596828HCID 86596828, compound

Procedure

(S)-N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-fluoro-2-methyl-malonamic acid was coupled with 3,3,4,4,4-pentafluoro-butylamine in analogy to the procedure described for example 73 to yield (R)-N-((S)-5-cyclopropylmethyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-2-fluoro-2-methyl-N′-(3,3,4,4,4-pentafluoro-butyl)-malonamide as white solid.

Sources & evidence

ORD record
ord-6bbc59969d5d4ecc89e890f44313393e
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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