反应详情

In an analogous manner to that described in Example 106a, the reaction of [(S)-2-oxo-1-(2,2,2-trifluoro-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester [Example 107b] with carbon dioxide and bromomethyl-cyclopropane in presence of cesium carbonate yielded the title compound as a white foam; MS: m/e=475 (M+NH4)+.