2-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid → HCID 86760355, compound

HRID 1372979Notes

Reaction equation

HRID 1372979 reaction equation
[C:1]([N:4]1[CH2:10][C@H:9]([NH2:11])[C:8](=[O:12])[N:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]2[CH:20]=[CH:21][CH:22]=[CH:23][C:5]1=2)(=[O:3])[CH3:2].[CH3:24][CH:25]([C:29]([NH:31][CH2:32][C:33]([F:39])([F:38])[C:34]([F:37])([F:36])[F:35])=[O:30])[C:26](O)=[O:27]>>[C:1]([N:4]1[CH2:10][C@H:9]([NH:11][C:26](=[O:27])[CH:25]([CH3:24])[C:29]([NH:31][CH2:32][C:33]([F:38])([F:39])[C:34]([F:35])([F:36])[F:37])=[O:30])[C:8](=[O:12])[N:7]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:6]2[CH:20]=[CH:21][CH:22]=[CH:23][C:5]1=2)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 210724942-Methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acidHCID 69037707HCID 69037707, compound

Product 1

HCID 86760355HCID 86760355, compound

Procedure

In an analogous manner to that described in Example 20 d) and 27, the condensation of (S)-5-acetyl-3-amino-1-benzyl-1,3,4,5-tetrahydro-benzo[b][1,4]diazepin-2-one and (2RS)-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid [see Example 25 b)] yielded the title compound as a white solid; MS: m/e=539 (M−H)−.

Workup

  1. customdescribed in Example 20 d

Sources & evidence

ORD record
ord-65ede4a2db184c61a2930ad75250473c
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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