3,3,3-Trifluoropropylamine → (R)-2-Fluoro-2-methyl-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(3,3,3-trifluoro-propyl)-malonamide

HRID 1372980Notes

Reaction equation

HRID 1372980 reaction equation
[F:1][C:2]([F:7])([F:6])[CH2:3][CH2:4][NH2:5].[F:8][C@@:9]([CH3:33])([C:13]([NH:15][C@@H:16]1[C:22](=[O:23])[N:21]([CH3:24])[C:20]2[CH:25]=[CH:26][CH:27]=[CH:28][C:19]=2[C:18]2[CH:29]=[CH:30][CH:31]=[CH:32][C:17]1=2)=[O:14])[C:10](O)=[O:11]>>[F:8][C@:9]([CH3:33])([C:10]([NH:5][CH2:4][CH2:3][C:2]([F:7])([F:6])[F:1])=[O:11])[C:13]([NH:15][C@@H:16]1[C:22](=[O:23])[N:21]([CH3:24])[C:20]2[CH:25]=[CH:26][CH:27]=[CH:28][C:19]=2[C:18]2[CH:29]=[CH:30][CH:31]=[CH:32][C:17]1=2)=[O:14]

Participants

3

Reactant 2

HCID 100013,3,3-TrifluoropropylamineHCID 69040656HCID 69040656, compound

Product 1

HCID 69043342(R)-2-Fluoro-2-methyl-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(3,3,3-trifluoro-propyl)-malonamide

Procedure

The title compound [MS m/e (%): 452.3 (M+H+, 100)]was prepared in analogy to example 14 from 3,3,3-trifluoropropylamine and (2S)-2-fluoro-2-methyl-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamic acid.

Sources & evidence

ORD record
ord-642ab95245ad43dcab8bdb8610cf7689
Source dataset
uspto-grants-2007_01
Patent number
US07160875B2

Reaction notes

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