Ammonia → HCID 135763119, compound

HRID 1372996Notes

Reaction equation

HRID 1372996 reaction equation
[OH:1][CH:2]([CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:23])[N:10](COC(=O)C(C)(C)C)[CH:11]=[N:12]2)=[CH:7][C:6]=1[O:24][CH3:25].N>CO>[OH:1][CH:2]([CH2:26][N:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1)[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:23])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[O:24][CH3:25]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21936032HCID 21936032, compound

Product 1

HCID 135763119HCID 135763119, compoundYield 95.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

7-(2-Hydroxy-3-(pyrrolidin-1-yl)propoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (7.8 g) was stirred for 48 hours in a solution of methanol saturated with ammonia (200 ml). The solvent was evaporated and the solid obtained was washed with ether (2×) and ether/dichloromethane (95:5, 2×100 ml) to give the 7-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (5.5 g).

Workup

  1. customThe solvent was evaporated
  2. customthe solid obtained
  3. washwas washed with ether (2×) and ether/dichloromethane (95:5, 2×100 ml)

Sources & evidence

ORD record
ord-609e4199614a4160be6833b61ceeb91e
Source dataset
uspto-grants-2007_01
Patent number
US07160889B2

Reaction notes

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