Ammonia → HCID 135763119, compound

Participants

Reaction Steps

7-(2-Hydroxy-3-(pyrrolidin-1-yl)propoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (7.8 g) was stirred for 48 hours in a solution of methanol saturated with ammonia (200 ml). The solvent was evaporated and the solid obtained was washed with ether (2×) and ether/dichloromethane (95:5, 2×100 ml) to give the 7-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (5.5 g).

Provenance & Evidence