Ammonia → HCID 136340819, compound

HRID 1372999Notes

Reaction equation

HRID 1372999 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[C:7]([NH:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:8]([O:15][CH2:16][CH:17]([O:24]C(=O)C)[CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[C:9]([O:13][CH3:14])[C:10]=2[OH:12])[N:5]=[C:4]([F:35])[N:3]=1.N>CO>[Br:1][C:2]1[C:11]2[C:6](=[C:7]([NH:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[C:8]([O:15][CH2:16][CH:17]([OH:24])[CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[C:9]([O:13][CH3:14])[C:10]=2[OH:12])[N:5]=[C:4]([F:35])[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 136340820HCID 136340820, compound

Product 1

HCID 136340819HCID 136340819, compoundYield 69.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using an analogous procedure to that described in Example 10, 4-bromo-2-fluoro-5-hydroxyphenylamino-7-[2-acetoxy-3-(pyrrolidin-1-yl)propoxy]-6-methoxyquinazoline (106 mg) was treated with methanol saturated with ammonia to give 4-bromo-2-fluoro-5-hydroxyphenylamino-7-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy]-6-methoxyquinazoline (68 mg)

Sources & evidence

ORD record
ord-8156d45b7798432ebb5406ee6b216fcd
Source dataset
uspto-grants-2007_01
Patent number
US07160889B2

Reaction notes

Loading…