HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 136340819, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 136340820 | HCID 136340820 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136340819 | HCID 136340819 | 69.5% |
Reaction Steps
Using an analogous procedure to that described in Example 10, 4-bromo-2-fluoro-5-hydroxyphenylamino-7-[2-acetoxy-3-(pyrrolidin-1-yl)propoxy]-6-methoxyquinazoline (106 mg) was treated with methanol saturated with ammonia to give 4-bromo-2-fluoro-5-hydroxyphenylamino-7-[2-hydroxy-3-(pyrrolidin-1-yl)propoxy]-6-methoxyquinazoline (68 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07160889B2 |
| Source dataset | uspto-grants-2007_01 |
| ORD ID | ord-8156d45b7798432ebb5406ee6b216fcd |
| Source note | uspto-grants-2007_01 |