Hydrogen Bromide → HCID 23020487, compound

HRID 1373014Notes

Reaction equation

HRID 1373014 reaction equation
Br.[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:12]=[N:13][C:14]([O:17]C)=[CH:15][CH:16]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1>C(O)(=O)C>[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][CH:12]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 23020480HCID 23020480, compound

Product 1

HCID 23020487HCID 23020487, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In a mixture solution of acetic acid and 48% hydrogen bromide, 2-amino-6-(3-fluorophenyl)-5-(6-methoxy-3-pyridyl)-3-methyl-3,4-dihydro-4-pyrimidinone was stirred at 100° C. for 2 hours. After cooling, the reaction solution was basified and washed with ethyl acetate. The aqueous layer was neutralized with diluted hydrochloric acid, and the resulting solid was collected by filtration, to give the title compound.

Workup

  1. temperatureAfter cooling
  2. washwashed with ethyl acetate
  3. filtrationthe resulting solid was collected by filtration

Sources & evidence

ORD record
ord-761ac9fdf60e4b17a2e2ccd7a1bdc88a
Source dataset
uspto-grants-2007_01
Patent number
US07160892B2

Reaction notes

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