HCID 23112193, compound → HCID 178453045, compound

HRID 1373070Notes

Reaction equation

HRID 1373070 reaction equation
[CH2:1]([N:8]([C@H:16]1[CH2:21][CH2:20][C@H:19]([NH:22][C:23]2[CH:32]=[CH:31][CH:30]=[C:29]3[C:24]=2[C:25]([CH:34]=[CH2:35])=[CH:26][N:27]=[C:28]3[Cl:33])[CH2:18][CH2:17]1)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(C1CCC(NC2C=CC=C3C=2C(C=C)=CN=C3)CC1)C(=O)OC(C)(C)C)C1C=CC=CC=1>>[CH2:1]([N:8]([C@H:16]1[CH2:21][CH2:20][C@H:19]([N:22]2[C:23]3=[C:24]4[C:29](=[CH:30][CH:31]=[CH:32]3)[C:28]([Cl:33])=[N:27][CH:26]=[C:25]4[CH2:34][CH2:35]2)[CH2:18][CH2:17]1)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 23112193HCID 23112193, compoundHCID 178437135HCID 178437135, compound

Product 1

HCID 178453045HCID 178453045, compound

Procedure

According to the method of Example 21, Step C, the tert-butyl trans-N-benzyl-[4-(1-chloro-4-vinylisoquinolin-5-yl)aminocyclohexyl]carbamate obtained in Step A mentioned above was used for the cyclization instead of the trans-isomer of Intermediate 10 to obtain the title compound.

Sources & evidence

ORD record
ord-897f4b419bd040e1b31beab969f125a5
Source dataset
uspto-grants-2007_01
Patent number
US07160894B2

Reaction notes

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